Major mints: Samosata, Zeugma.

Kommagene was located in the most northerly part of Syria. The district was a small client kingdom of the Seleukids, then of the Romans, from the middle of the second century BC, when the decay of the Seleukids allowed some of the more distant provinces to secede. Their capital was Samosata, founded by king Samos around 150 BC. Tiberius made it a Roman province in AD 17, but Caligula restored the kingdom for his friend Antiochos IV in 38. On his death in 72 it reverted to Rome.

Samosata issued some civic coins under the kings; it also had a reasonably extensive series of Imperial issues. Zeugma, whose name means bridge, founded by Seleucus I as Seleucia on the Euphrates, issued coins with the type of a temple of Zeus with sacred grove; this was the main temple of the city, located on the acropolis.